| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 3 |
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| Ligand | BDBM50446144 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1287960 (CHEMBL3110531) |
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| Ki | 10000±n/a nM |
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| Citation |  Haftchenary, S; Luchman, HA; Jouk, AO; Veloso, AJ; Page, BD; Cheng, XR; Dawson, SS; Grinshtein, N; Shahani, VM; Kerman, K; Kaplan, DR; Griffin, C; Aman, AM; Al-Awar, R; Weiss, S; Gunning, PT Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma. ACS Med Chem Lett4:1102-7 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Signal transducer and activator of transcription 3 |
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| Name: | Signal transducer and activator of transcription 3 |
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| Synonyms: | APRF | STAT3 | STAT3_HUMAN | Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) |
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| Type: | Protein |
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| Mol. Mass.: | 88064.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P40763 |
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| Residue: | 770 |
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| Sequence: | MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
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| BDBM50446144 |
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| n/a |
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| Name | BDBM50446144 |
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| Synonyms: | CHEMBL3108911 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H26F6N2O5S |
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| Mol. Mass. | 628.583 |
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| SMILES | CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(F)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F |
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| Structure | 
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