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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Aurora kinase B | ||
| Ligand | BDBM50446433 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1287773 | ||
| IC50 | 16000±n/a nM | ||
| Citation |  Naud S; Westwood IM; Faisal A; Sheldrake P; Bavetsias V; Atrash B; Cheung KM; Liu M; Hayes A; Schmitt J; Wood A; Choi V; Boxall K; Mak G; Gurden M; Valenti M; de Haven Brandon A; Henley A; Baker R; McAndrew C; Matijssen B; Burke R; Hoelder S; Eccles SA; Raynaud FI; Linardopoulos S; van Montfort RL; Blagg J Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem 56:10045-65 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Aurora kinase B | |||
| Name: | Aurora kinase B | ||
| Synonyms: | AIM-1 | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | Serine/threonine-protein kinase aurora B | ||
| Type: | Protein | ||
| Mol. Mass.: | 39327.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q96GD4 | ||
| Residue: | 344 | ||
| Sequence: |
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| BDBM50446433 | |||
| n/a | |||
| Name | BDBM50446433 | ||
| Synonyms: | CHEMBL3109963 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H18N4O2 | ||
| Mol. Mass. | 334.3718 | ||
| SMILES | COc1ccccc1Nc1cc2[nH]c(cc2cn1)-c1c(C)noc1C | ||
| Structure | 
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