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TargetAurora kinase B
LigandBDBM50446454
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1287773 (CHEMBL3111605)
IC50>100000±n/a nM
Citation Naud, SWestwood, IMFaisal, ASheldrake, PBavetsias, VAtrash, BCheung, KMLiu, MHayes, ASchmitt, JWood, AChoi, VBoxall, KMak, GGurden, MValenti, Mde Haven Brandon, AHenley, ABaker, RMcAndrew, CMatijssen, BBurke, RHoelder, SEccles, SARaynaud, FILinardopoulos, Svan Montfort, RLBlagg, J Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem56:10045-65 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Aurora kinase B
Name:Aurora kinase B
Synonyms:AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:Protein
Mol. Mass.:39327.72
Organism:Homo sapiens (Human)
Description:Q96GD4
Residue:344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50446454
n/a
NameBDBM50446454
Synonyms:CHEMBL3109959
TypeSmall organic molecule
Emp. Form.C18H15F2N5O
Mol. Mass.355.3414
SMILESCOc1ccccc1Nc1cc2[nH]c(cc2cn1)-c1cnn(c1)C(F)F
Structure
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