| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl hydroxylase EGLN2 |
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| Ligand | BDBM50385806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1290292 (CHEMBL3118614) |
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| IC50 | 0.200000±n/a nM |
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| Citation |  Rabinowitz, MH Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses. J Med Chem56:9369-402 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl hydroxylase EGLN2 |
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| Name: | Prolyl hydroxylase EGLN2 |
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| Synonyms: | EGLN2 | EGLN2_HUMAN | EIT6 | Egl nine homolog 2 | Estrogen-induced tag 6 | HIF prolyl hydroxylase | HIF-PH1 | HIF-prolyl hydroxylase 1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase | PHD1 | Prolyl hydroxylase domain-containing protein 1 | Prolyl hydroxylase domain-containing protein 1 (PHD1) |
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| Type: | Protein |
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| Mol. Mass.: | 43657.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96KS0 |
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| Residue: | 407 |
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| Sequence: | MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAG
SGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALVTKGCQRLAAQGARPEAPKRK
WAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALD
YIVPCMRYYGICVKDSFLGAALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQI
AWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEV
KPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPVSQPPTPT
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| BDBM50385806 |
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| n/a |
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| Name | BDBM50385806 |
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| Synonyms: | CHEMBL2041193 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H30N6O4 |
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| Mol. Mass. | 562.6184 |
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| SMILES | Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccc(cc1C)C(O)=O)c1ccncn1 |
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| Structure | 
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