| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase SIK1 |
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| Ligand | BDBM50446982 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1291248 (CHEMBL3117033) |
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| IC50 | 190±n/a nM |
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| Citation |  Su, Q; Ioannidis, S; Chuaqui, C; Almeida, L; Alimzhanov, M; Bebernitz, G; Bell, K; Block, M; Howard, T; Huang, S; Huszar, D; Read, JA; Rivard Costa, C; Shi, J; Su, M; Ye, M; Zinda, M Discovery of 1-methyl-1H-imidazole derivatives as potent Jak2 inhibitors. J Med Chem57:144-58 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase SIK1 |
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| Name: | Serine/threonine-protein kinase SIK1 |
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| Synonyms: | SIK | SIK1 | SIK1_HUMAN | SNF1LK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84908.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774213 |
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| Residue: | 783 |
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| Sequence: | MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK
TRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGH
LSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPL
STWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGR
FRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSN
LGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPAR
QPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQPQTLVQSVLQAEMDCELQSSLQWPLFFP
VDASCSGVFRPRPVSPSSLLDTAISEEARQGPGLEEEQDTQESLPSSTGRRHTLAEVSTR
LSPLTAPCIVVSPSTTASPAEGTSSDSCLTFSASKSPAGLSGTPATQGLLGACSPVRLAS
PFLGSQSATPVLQAQGGLGGAVLLPVSFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFL
GLNKIKGLARQVCQAPASRASRGGLSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRL
LQLQHHPAAAPGCSQAPQPAPAPFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASP
VASAAQLLDTHLHIGTGPTALPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFV
LVQ
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| BDBM50446982 |
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| n/a |
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| Name | BDBM50446982 |
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| Synonyms: | CHEMBL3116050 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16FN9 |
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| Mol. Mass. | 353.3569 |
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| SMILES | C[C@H](Nc1nc(Nc2cn(C)cn2)c2cc[nH]c2n1)c1ncc(F)cn1 |r| |
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| Structure | 
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