| Reaction Details |
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 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, dimeric NADP-preferring |
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| Ligand | BDBM62312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289633 (CHEMBL3118331) |
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| IC50 | 700±n/a nM |
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| Citation |  Parajuli, B; Fishel, ML; Hurley, TD Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. J Med Chem57:449-61 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldehyde dehydrogenase, dimeric NADP-preferring |
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| Name: | Aldehyde dehydrogenase, dimeric NADP-preferring |
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| Synonyms: | AL3A1_HUMAN | ALDH3 | ALDH3A1 | Aldehyde dehydrogenase 3A1 (ALDH3A1) | Aldehyde dehydrogenase family 3 member A1 (ALDH3A1) | Aldehyde dehydrogenase family 3 member A1 (ALDH3A1) (Q122A) |
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| Type: | Protein |
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| Mol. Mass.: | 50394.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 453 |
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| Sequence: | MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
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| BDBM62312 |
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| n/a |
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| Name | BDBM62312 |
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| Synonyms: | 2-methyl-1-(4-methylphenyl)sulfonyl-benzimidazole | 2-methyl-1-(4-methylphenyl)sulfonylbenzimidazole | 2-methyl-1-tosyl-benzimidazole | MLS-0350366.0001 | US9328112, A10 | cid_755364 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2O2S |
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| Mol. Mass. | 286.349 |
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| SMILES | Cc1nc2ccccc2n1S(=O)(=O)c1ccc(C)cc1 |
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| Structure | 
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