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TargetPolyunsaturated fatty acid lipoxygenase ALOX12
LigandBDBM50447177
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1290553 (CHEMBL3116602)
IC50 570±n/a nM
Citation Luci, DKJameson, JBYasgar, ADiaz, GJoshi, NKantz, AMarkham, KPerry, SKuhn, NYeung, JKerns, EHSchultz, LHolinstat, MNadler, JLTaylor-Fishwick, DAJadhav, ASimeonov, AHolman, TRMaloney, DJ Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem57:495-506 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyunsaturated fatty acid lipoxygenase ALOX12
Name:Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12
Type:Protein
Mol. Mass.:75689.18
Organism:Homo sapiens (Human)
Description:P18054
Residue:663
Sequence:
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLL
QFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNA
LDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKA
GALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPML
LRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPL
VMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYH
LLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVST
GGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVH
LFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQH
AAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRR
QPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENS
VTI
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  Blast E-value cutoff:
BDBM50447177
n/a
NameBDBM50447177
Synonyms:CHEMBL3113167 | US10752581, Compound 37
TypeSmall organic molecule
Emp. Form.C21H20N4O4S
Mol. Mass.424.473
SMILESCOc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2nc3ccccc3[nH]2)c1O
Structure
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