| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50447312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1291282 (CHEMBL3117272) |
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| IC50 | 20±n/a nM |
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| Citation |  Kale, RR; Kale, MG; Waterson, D; Raichurkar, A; Hameed, SP; Manjunatha, MR; Kishore Reddy, BK; Malolanarasimhan, K; Shinde, V; Koushik, K; Jena, LK; Menasinakai, S; Humnabadkar, V; Madhavapeddi, P; Basavarajappa, H; Sharma, S; Nandishaiah, R; Mahesh Kumar, KN; Ganguly, S; Ahuja, V; Gaonkar, S; Naveen Kumar, CN; Ogg, D; Boriack-Sjodin, PA; Sambandamurthy, VK; de Sousa, SM; Ghorpade, SR Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy. Bioorg Med Chem Lett24:870-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50447312 |
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| n/a |
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| Name | BDBM50447312 |
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| Synonyms: | CHEMBL3114222 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N5O2S |
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| Mol. Mass. | 411.521 |
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| SMILES | CCNC(=O)Nc1nc2cc(-c3cccnc3)c(=O)n(CC3CCCCC3)c2s1 |
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| Structure | 
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