Reaction Details |
| Report a problem with these data |
Target | Alkaline phosphatase, placental type |
---|
Ligand | BDBM50447413 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1288274 (CHEMBL3117348) |
---|
IC50 | >100000±n/a nM |
---|
Citation | Ardecky, RJ; Bobkova, EV; Kiffer-Moreira, T; Brown, B; Ganji, S; Zou, J; Pass, I; Narisawa, S; Iano, FG; Rosenstein, C; Cheltsov, A; Rascon, J; Hedrick, M; Gasior, C; Forster, A; Shi, S; Dahl, R; Vasile, S; Su, Y; Sergienko, E; Chung, TD; Kaunitz, J; Hoylaerts, MF; Pinkerton, AB; Millán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett24:1000-4 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Alkaline phosphatase, placental type |
---|
Name: | Alkaline phosphatase, placental type |
Synonyms: | ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 57950.65 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1506090 |
Residue: | 535 |
Sequence: | MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
|
|
|
BDBM50447413 |
---|
n/a |
---|
Name | BDBM50447413 |
Synonyms: | CHEMBL3115157 |
Type | Small organic molecule |
Emp. Form. | C17H17N3O5S |
Mol. Mass. | 375.399 |
SMILES | Cc1ccc(C)c(NC(=O)CNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)c1 |
Structure |
|