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TargetAlkaline phosphatase, placental type
LigandBDBM50447413
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1288274 (CHEMBL3117348)
IC50>100000±n/a nM
Citation Ardecky, RJBobkova, EVKiffer-Moreira, TBrown, BGanji, SZou, JPass, INarisawa, SIano, FGRosenstein, CCheltsov, ARascon, JHedrick, MGasior, CForster, AShi, SDahl, RVasile, SSu, YSergienko, EChung, TDKaunitz, JHoylaerts, MFPinkerton, ABMillán, JL Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes. Bioorg Med Chem Lett24:1000-4 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, placental type
Name:Alkaline phosphatase, placental type
Synonyms:ALPP | Alkaline phosphatase placental type | PLAP | PPB1_HUMAN
Type:PROTEIN
Mol. Mass.:57950.65
Organism:Homo sapiens (Human)
Description:ChEMBL_1506090
Residue:535
Sequence:
MLGPCMLLLLLLLGLRLQLSLGIIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLII
FLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATA
YLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAG
TYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYP
DDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEI
HRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAI
ERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG
YVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFI
AHVMAFAACLEPYTACDLAPPAGTTDAAHPGRSVVPALLPLLAGTLLLLETATAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50447413
n/a
NameBDBM50447413
Synonyms:CHEMBL3115157
TypeSmall organic molecule
Emp. Form.C17H17N3O5S
Mol. Mass.375.399
SMILESCc1ccc(C)c(NC(=O)CNS(=O)(=O)c2ccc3[nH]c(=O)oc3c2)c1
Structure
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