Reaction Details |
| Report a problem with these data |
Target | NUAK family SNF1-like kinase 1 |
---|
Ligand | BDBM6309 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1288874 (CHEMBL3117359) |
---|
IC50 | >5000±n/a nM |
---|
Citation | Reddy, MV; Akula, B; Cosenza, SC; Athuluridivakar, S; Mallireddigari, MR; Pallela, VR; Billa, VK; Subbaiah, DR; Bharathi, EV; Vasquez-Del Carpio, R; Padgaonkar, A; Baker, SJ; Reddy, EP Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5). J Med Chem57:578-99 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
NUAK family SNF1-like kinase 1 |
---|
Name: | NUAK family SNF1-like kinase 1 |
Synonyms: | ARK5 | KIAA0537 | NUAK1 | NUAK1_HUMAN | OMPHK1 |
Type: | PROTEIN |
Mol. Mass.: | 74326.51 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1451343 |
Residue: | 661 |
Sequence: | MEGAAAPVAGDRPDLGLGAPGSPREAVAGATAALEPRKPHGVKRHHHKHNLKHRYELQET
LGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHIISIYE
VFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLK
LENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDSWALG
VLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPSDARGLIRWMLMVNPDRRATIEDI
ANHWWVNWGYKSSVCDCDALHDSESPLLARIIDWHHRSTGLQADTEAKMKGLAKPTTSEV
MLERQRSLKKSKKENDFAQSGQDAVPESPSKLSSKRPKGILKKRSNSEHRSHSTGFIEGV
VGPALPSTFKMEQDLCRTGVLLPSSPEAEVPGKLSPKQSATMPKKGILKKTQQRESGYYS
SPERSESSELLDSNDVMGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKYSAGTMDPAL
VSPEMPTLESLSEPGVPAEGLSRSYSRPSSVISDDSVLSSDSFDLLDLQENRPARQRIRS
CVSAENFLQIQDFEGLQNRPRPQYLKRYRNRLADSSFSLLTDMDDVTQVYKQALEICSKL
N
|
|
|
BDBM6309 |
---|
n/a |
---|
Name | BDBM6309 |
Synonyms: | 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride | 8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one | Ibrance | PD 0332991 | Palbociclib | Pyrido-[2,3-d]-pyrimidin-7-one 43 | US10189849, PD0332991 | US10464927, Compound Palbociclib | US10626107, Example Palbociclib | US10696682, Compound PD0332991 | US10927120, PD0332991 | US9464092, PD0332991 | US9957276, PD0332991 |
Type | Small organic molecule |
Emp. Form. | C24H29N7O2 |
Mol. Mass. | 447.5328 |
SMILES | CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O |
Structure |
|