Reaction Details |
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Target | Vitamin K-dependent protein C |
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Ligand | BDBM50447515 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1289213 (CHEMBL3119480) |
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IC50 | 130±n/a nM |
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Citation | Bach, P; Knerr, L; Fjellström, O; Hansson, K; Mattsson, C; Gustafsson, D Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia. Bioorg Med Chem Lett24:821-7 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Vitamin K-dependent protein C |
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Name: | Vitamin K-dependent protein C |
Synonyms: | Activated protein C cofactor | Anticoagulant protein C | Apolipoprotein H | Autoprothrombin IIA | Blood coagulation factor XIV | Coagulation factor V | Coagulation factor V heavy chain | Coagulation factor V light chain | Endothelial protein C receptor | PROC | PROC_HUMAN | Proaccelerin, labile factor | Vitamin K-dependent protein C precursor |
Type: | Enzyme |
Mol. Mass.: | 52067.73 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 461 |
Sequence: | MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
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BDBM50447515 |
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n/a |
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Name | BDBM50447515 |
Synonyms: | CHEMBL3115901 |
Type | Small organic molecule |
Emp. Form. | C28H38N6O4 |
Mol. Mass. | 522.6391 |
SMILES | NC(=N)c1ccc(CNC(=O)[C@H](Cc2ccc(N)cc2)NC(=O)[C@@H](CC2CCCCC2)NCC(O)=O)cc1 |r| |
Structure |
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