| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
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| Ligand | BDBM50447951 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1288598 (CHEMBL3119218) |
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| IC50 | 630±n/a nM |
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| Citation |  Nakao, S; Mabuchi, M; Shimizu, T; Itoh, Y; Takeuchi, Y; Ueda, M; Mizuno, H; Shigi, N; Ohshio, I; Jinguji, K; Ueda, Y; Yamamoto, M; Furukawa, T; Aoki, S; Tsujikawa, K; Tanaka, A Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer drugs. Bioorg Med Chem Lett24:1071-4 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
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| Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
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| Synonyms: | ABH3 | ALKB3_HUMAN | ALKBH3 | Alkylated DNA repair protein alkB homolog 3 | DEPC-1 | DEPC1 | Prostate cancer antigen 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33382.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108024 |
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| Residue: | 286 |
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| Sequence: | MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQ
QVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTG
IREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNL
YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLD
HGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW
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| BDBM50447951 |
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| n/a |
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| Name | BDBM50447951 |
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| Synonyms: | CHEMBL3114999 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N4O2 |
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| Mol. Mass. | 334.3718 |
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| SMILES | COc1ccc(Cc2c(C)[nH]n(-c3nc4ccccc4[nH]3)c2=O)cc1 |
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| Structure | 
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