Reaction Details |
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Target | Sodium- and chloride-dependent glycine transporter 1 |
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Ligand | BDBM50448013 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1288773 (CHEMBL3116694) |
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IC50 | 15±n/a nM |
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Citation | Sheffler, DJ; Nedelovych, MT; Williams, R; Turner, SC; Duerk, BB; Robbins, MR; Jadhav, SB; Niswender, CM; Jones, CK; Conn, PJ; Daniels, RN; Lindsley, CW Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. Bioorg Med Chem Lett24:1062-6 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium- and chloride-dependent glycine transporter 1 |
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Name: | Sodium- and chloride-dependent glycine transporter 1 |
Synonyms: | GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9 |
Type: | Enzyme |
Mol. Mass.: | 78270.54 |
Organism: | Homo sapiens (Human) |
Description: | P48067 |
Residue: | 706 |
Sequence: | MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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BDBM50448013 |
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n/a |
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Name | BDBM50448013 |
Synonyms: | CHEMBL3115220 |
Type | Small organic molecule |
Emp. Form. | C17H19Cl2N5O3S |
Mol. Mass. | 444.335 |
SMILES | Cn1cc(nn1)S(=O)(=O)N1CC2CCC(NC(=O)c3ccc(Cl)cc3Cl)C2C1 |
Structure |
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