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TargetUrease
LigandBDBM50448175
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1293003 (CHEMBL3122982)
Ki 8600±n/a nM
Citation Khan, KMNaz, FTaha, MKhan, APerveen, SChoudhary, MIVoelter, W Synthesis and in vitro urease inhibitory activity of N,N'-disubstituted thioureas. Eur J Med Chem74:314-23 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urease
Name:Urease
Synonyms:UREA_CANEN | Urea amidohydrolase
Type:Enzyme
Mol. Mass.:90746.20
Organism:Canavalia ensiformis (Jack bean) (Horse bean)
Description:P07374
Residue:840
Sequence:
MKLSPREVEKLGLHNAGYLAQKRLARGVRLNYTEAVALIASQIMEYARDGEKTVAQLMCL
GQHLLGRRQVLPAVPHLLNAVQVEATFPDGTKLVTVHDPISRENGELQEALFGSLLPVPS
LDKFAETKEDNRIPGEILCEDECLTLNIGRKAVILKVTSKGDRPIQVGSHYHFIEVNPYL
TFDRRKAYGMRLNIAAGTAVRFEPGDCKSVTLVSIEGNKVIRGGNAIADGPVNETNLEAA
MHAVRSKGFGHEEEKDASEGFTKEDPNCPFNTFIHRKEYANKYGPTTGDKIRLGDTNLLA
EIEKDYALYGDECVFGGGKVIRDGMGQSCGHPPAISLDTVITNAVIIDYTGIIKADIGIK
DGLIASIGKAGNPDIMNGVFSNMIIGANTEVIAGEGLIVTAGAIDCHVHYICPQLVYEAI
SSGITTLVGGGTGPAAGTRATTCTPSPTQMRLMLQSTDDLPLNFGFTGKGSSSKPDELHE
IIKAGAMGLKLHEDWGSTPAAIDNCLTIAEHHDIQINIHTDTLNEAGFVEHSIAAFKGRT
IHTYHSEGAGGGHAPDIIKVCGIKNVLPSSTNPTRPLTSNTIDEHLDMLMVCHHLDREIP
EDLAFAHSRIRKKTIAAEDVLNDIGAISIISSDSQAMGRVGEVISRTWQTADKMKAQTGP
LKCDSSDNDNFRIRRYIAKYTINPAIANGFSQYVGSVEVGKLADLVMWKPSFFGTKPEMV
IKGGMVAWADIGDPNASIPTPEPVKMRPMYGTLGKAGGALSIAFVSKAALDQRVNVLYGL
NKRVEAVSNVRKLTKLDMKLNDALPEITVDPESYTVKADGKLLCVSEATTVPLSRNYFLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50448175
n/a
NameBDBM50448175
Synonyms:CHEMBL3120552
TypeSmall organic molecule
Emp. Form.C12H11N3S
Mol. Mass.229.301
SMILESS=C(Nc1ccccc1)Nc1cccnc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: