| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine proteinase falcipain 3 |
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| Ligand | BDBM50448261 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1293361 (CHEMBL3122304) |
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| IC50 | 540±n/a nM |
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| Citation |  Weldon, DJ; Shah, F; Chittiboyina, AG; Sheri, A; Chada, RR; Gut, J; Rosenthal, PJ; Shivakumar, D; Sherman, W; Desai, P; Jung, JC; Avery, MA Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis ofa-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett24:1274-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine proteinase falcipain 3 |
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| Name: | Cysteine proteinase falcipain 3 |
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| Synonyms: | Cysteine protease falcipain-3 |
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| Type: | Protein |
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| Mol. Mass.: | 56666.98 |
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| Organism: | Plasmodium falciparum |
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| Description: | Q9NAW4 |
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| Residue: | 492 |
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| Sequence: | MEYHMEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNEN
NKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMN
MNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNK
KYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGP
FKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVG
SVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSN
LPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECG
AAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTC
SIGTEAYVPLLE
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| BDBM50448261 |
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| n/a |
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| Name | BDBM50448261 |
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| Synonyms: | CHEMBL3120834 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N2O5 |
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| Mol. Mass. | 452.5427 |
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| SMILES | OCC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H]1CCCC[C@@H]1NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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