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TargetDihydrofolate reductase
LigandBDBM50448351
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294109 (CHEMBL3122687)
Ki 4000±n/a nM
Citation Piras, SCarta, ABriguglio, ICorona, PPaglietti, GLuciani, RCosti, MPFerrari, S 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem75:169-83 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50448351
n/a
NameBDBM50448351
Synonyms:CHEMBL3121446
TypeSmall organic molecule
Emp. Form.C34H35F3N4O5
Mol. Mass.636.6607
SMILESCCOC(=O)CC[C@H](NC(=O)c1ccc(cc1)N(CC)Cc1nc2cc(ccc2nc1-c1ccccc1)C(F)(F)F)C(=O)OCC |r|
Structure
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