Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50448351 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294109 (CHEMBL3122687) |
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Ki | 4000±n/a nM |
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Citation | Piras, S; Carta, A; Briguglio, I; Corona, P; Paglietti, G; Luciani, R; Costi, MP; Ferrari, S 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem75:169-83 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50448351 |
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n/a |
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Name | BDBM50448351 |
Synonyms: | CHEMBL3121446 |
Type | Small organic molecule |
Emp. Form. | C34H35F3N4O5 |
Mol. Mass. | 636.6607 |
SMILES | CCOC(=O)CC[C@H](NC(=O)c1ccc(cc1)N(CC)Cc1nc2cc(ccc2nc1-c1ccccc1)C(F)(F)F)C(=O)OCC |r| |
Structure |
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