| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50448366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1294109 (CHEMBL3122687) |
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| Ki | 5000±n/a nM |
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| Citation |  Piras, S; Carta, A; Briguglio, I; Corona, P; Paglietti, G; Luciani, R; Costi, MP; Ferrari, S 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. Eur J Med Chem75:169-83 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50448366 |
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| n/a |
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| Name | BDBM50448366 |
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| Synonyms: | CHEMBL3121459 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H17F4N3 |
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| Mol. Mass. | 411.3948 |
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| SMILES | CN(Cc1nc2cc(ccc2nc1-c1ccccc1)C(F)(F)F)c1ccc(F)cc1 |
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| Structure | 
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