| Reaction Details |
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 | Report a problem with these data |
| Target | Leukocyte tyrosine kinase receptor |
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| Ligand | BDBM50448449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296026 (CHEMBL3131076) |
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| IC50 | 10600±n/a nM |
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| Citation |  Shahani, VM; Ball, DP; Ramos, AV; Li, Z; Spagnuolo, PA; Haftchenary, S; Schimmer, AD; Trudel, S; Gunning, PT A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells. Bioorg Med Chem21:5618-28 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Leukocyte tyrosine kinase receptor |
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| Name: | Leukocyte tyrosine kinase receptor |
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| Synonyms: | LTK | LTK_HUMAN | TYK1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91679.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586334 |
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| Residue: | 864 |
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| Sequence: | MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
SSGLKPLKSRGLQPQNLWNPTYRS
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| BDBM50448449 |
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| n/a |
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| Name | BDBM50448449 |
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| Synonyms: | CHEMBL3125667 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30FN7O3S |
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| Mol. Mass. | 539.625 |
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| SMILES | NS(=O)(=O)OCCn1cnc2c(Nc3ccc(F)cc3)nc(NCc3ccc(cc3)C3CCCCC3)nc12 |
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| Structure | 
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