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TargetThyroid hormone receptor beta
LigandBDBM50448463
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1297822 (CHEMBL3131648)
EC50 590±n/a nM
Citation Takahashi, NMaeda, KAsano, YWatanabe, N Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptorß agonists. Bioorg Med Chem22:488-98 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM50448463
n/a
NameBDBM50448463
Synonyms:CHEMBL3126367
TypeSmall organic molecule
Emp. Form.C21H22N2O4
Mol. Mass.366.4104
SMILESCC(C)c1cc(Cn2c(C)cc3c(NC(=O)C(O)=O)cccc23)ccc1O
Structure
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