| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thyroid hormone receptor alpha |
|---|
| Ligand | BDBM50448465 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1297826 (CHEMBL3131652) |
|---|
| IC50 | 3400±n/a nM |
|---|
| Citation |  Takahashi, N; Maeda, K; Asano, Y; Watanabe, N Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptorß agonists. Bioorg Med Chem22:488-98 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thyroid hormone receptor alpha |
|---|
| Name: | Thyroid hormone receptor alpha |
|---|
| Synonyms: | C-erbA-alpha | EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THA_HUMAN | THRA | THRA1 | THRA2 | Thyroid Hormone Receptor (TR-alpha) | Thyroid hormone receptor | Thyroid hormone receptor alpha | Thyroid hormone receptor apha | c-erbA-1 |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 54818.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRalpha 1. |
|---|
| Residue: | 490 |
|---|
| Sequence: | MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA
TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM
AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA
QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS
ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF
ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI
PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL
GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC
EDLAGNAASP
|
|
|
|---|
| BDBM50448465 |
|---|
| n/a |
|---|
| Name | BDBM50448465 |
|---|
| Synonyms: | CHEMBL3126375 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H27NO3 |
|---|
| Mol. Mass. | 365.4654 |
|---|
| SMILES | CC(C)c1cc(Cn2c(C)c(CCCC(O)=O)c3ccccc23)ccc1O |
|---|
| Structure | 
|
|---|
Search and Browse
