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TargetProtein arginine N-methyltransferase 1
LigandBDBM50448485
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294380
IC50 300000±n/a nM
Citation Valente SLiu YSchnekenburger MZwergel CCosconati SGros CTardugno MLabella DFlorean CMinden SHashimoto HChang YZhang XKirsch GNovellino EArimondo PBMiele EFerretti EGulino ADiederich MCheng XMai A Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem 57:701-13 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein arginine N-methyltransferase 1
Name:Protein arginine N-methyltransferase 1
Synonyms:Histone-arginine N-methyltransferase PRMT1 | Hrmt1l2 | Prmt1
Type:PROTEIN
Mol. Mass.:40514.94
Organism:Rattus norvegicus
Description:ChEMBL_103589
Residue:353
Sequence:
MAAAEAANCIMEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRN
SMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHV
VTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLHARDKWLAPDGLIFPDRATL
YVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIY
TVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFY
MEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
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  Blast E-value cutoff:
BDBM50448485
n/a
NameBDBM50448485
Synonyms:CHEMBL3126645
TypeSmall organic molecule
Emp. Form.C27H23N7O
Mol. Mass.461.5178
SMILESCc1cc(Nc2ccc(NC(=O)c3cccc(Nc4ccnc5ccccc45)c3)cc2)nc(N)n1
Structure
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