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TargetDNA (cytosine-5)-methyltransferase 3-like
LigandBDBM50448484
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1294383
IC50 2800±n/a nM
Citation Valente SLiu YSchnekenburger MZwergel CCosconati SGros CTardugno MLabella DFlorean CMinden SHashimoto HChang YZhang XKirsch GNovellino EArimondo PBMiele EFerretti EGulino ADiederich MCheng XMai A Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem 57:701-13 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA (cytosine-5)-methyltransferase 3-like
Name:DNA (cytosine-5)-methyltransferase 3-like
Synonyms:DNMT3L
Type:PROTEIN
Mol. Mass.:43578.37
Organism:Homo sapiens (Human)
Description:ChEMBL_108147
Residue:386
Sequence:
MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQ
VHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFE
CVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFE
TVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDL
VYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASR
FLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWP
TKLVKNCFLPLREYFKYFSTELTSSL
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  Blast E-value cutoff:
BDBM50448484
n/a
NameBDBM50448484
Synonyms:CHEMBL3126646
TypeSmall organic molecule
Emp. Form.C27H23N7O
Mol. Mass.461.5178
SMILESCc1cc(Nc2cccc(NC(=O)c3cccc(Nc4ccnc5ccccc45)c3)c2)nc(N)n1
Structure
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