Reaction Details |
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Target | Cytochrome P450 2D6 |
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Ligand | BDBM50448497 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294675 (CHEMBL3128631) |
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EC50 | >40000±n/a nM |
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Citation | Gentles, RG; Ding, M; Bender, JA; Bergstrom, CP; Grant-Young, K; Hewawasam, P; Hudyma, T; Martin, S; Nickel, A; Regueiro-Ren, A; Tu, Y; Yang, Z; Yeung, KS; Zheng, X; Chao, S; Sun, JH; Beno, BR; Camac, DM; Chang, CH; Gao, M; Morin, PE; Sheriff, S; Tredup, J; Wan, J; Witmer, MR; Xie, D; Hanumegowda, U; Knipe, J; Mosure, K; Santone, KS; Parker, DD; Zhuo, X; Lemm, J; Liu, M; Pelosi, L; Rigat, K; Voss, S; Wang, Y; Wang, YK; Colonno, RJ; Gao, M; Roberts, SB; Gao, Q; Ng, A; Meanwell, NA; Kadow, JF Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem57:1855-79 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2D6 |
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Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM50448497 |
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n/a |
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Name | BDBM50448497 |
Synonyms: | CHEMBL3126834 |
Type | Small organic molecule |
Emp. Form. | C35H43N5O5S |
Mol. Mass. | 645.811 |
SMILES | COc1ccc2-c3c(C4CCCCC4)c4ccc(cc4n3C[C@]3(C[C@H]3c2c1)C(=O)N1C2CC1CN(C)C2)C(=O)NS(=O)(=O)N(C)C |r,TLB:27:29:36.34.33:31,THB:35:34:29:31| |
Structure |
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