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TargetDihydrofolate reductase
LigandBDBM50448757
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1298221 (CHEMBL3130226)
Ki 0.005000±n/a nM
Citation Lam, THilgers, MTCunningham, MLKwan, BPNelson, KJBrown-Driver, VOng, VTrzoss, MHough, GShaw, KJFinn, J Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines. J Med Chem57:651-68 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_STAAU | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase (DfrB) | Tetrahydrofolate dehydrogenase | folA
Type:Enzyme
Mol. Mass.:18249.71
Organism:Staphylococcus aureus
Description:n/a
Residue:159
Sequence:
MTLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRN
VVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRG
DTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRKK
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BDBM50448757
n/a
NameBDBM50448757
Synonyms:CHEMBL3128025 | US8835445, 18
TypeSmall organic molecule
Emp. Form.C21H18N6S
Mol. Mass.386.473
SMILESCc1cc2nc(-c3cccs3)n(-c3ccc4c(N)nc(N)nc4c3)c2cc1C
Structure
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