Reaction Details |
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Target | Serine/threonine-protein kinase PAK 1 |
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Ligand | BDBM50448773 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1294409 (CHEMBL3129194) |
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Ki | >4500±n/a nM |
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Citation | Staben, ST; Feng, JA; Lyle, K; Belvin, M; Boggs, J; Burch, JD; Chua, CC; Cui, H; DiPasquale, AG; Friedman, LS; Heise, C; Koeppen, H; Kotey, A; Mintzer, R; Oh, A; Roberts, DA; Rouge, L; Rudolph, J; Tam, C; Wang, W; Xiao, Y; Young, A; Zhang, Y; Hoeflich, KP Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. J Med Chem57:1033-45 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase PAK 1 |
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Name: | Serine/threonine-protein kinase PAK 1 |
Synonyms: | 2.7.11.1 | Alpha-PAK | Cell division control protein 42 homolog | PAK 1/CDC42 | PAK-1 | PAK1 | PAK1_HUMAN | Serine/threonine-protein kinase PAK 1/PAK 2/PAK 3 | p21-activated kinase 1 | p65-PAK |
Type: | n/a |
Mol. Mass.: | 60640.15 |
Organism: | Homo sapiens (Human) |
Description: | Q13153 |
Residue: | 545 |
Sequence: | MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNALNVKAVSETPAVPPVSEDEDDD
DDDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDVATSPISPTENNTTPPDALTRNTE
KQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQ
MNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC
MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK
RSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNG
TPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEA
TKNNH
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BDBM50448773 |
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n/a |
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Name | BDBM50448773 |
Synonyms: | CHEMBL3128057 |
Type | Small organic molecule |
Emp. Form. | C16H15N5O |
Mol. Mass. | 293.3232 |
SMILES | CC(C)(O)C#Cc1ccc2cnn(-c3ccnc(N)n3)c2c1 |
Structure |
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