Ki Summary

Reaction Details

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Target

Serine/threonine-protein kinase PAK 4

Ligand

BDBM50448772

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1294410 (CHEMBL3129195)

140±n/a nM

Citation

Staben, ST; Feng, JA; Lyle, K; Belvin, M; Boggs, J; Burch, JD; Chua, CC; Cui, H; DiPasquale, AG; Friedman, LS; Heise, C; Koeppen, H; Kotey, A; Mintzer, R; Oh, A; Roberts, DA; Rouge, L; Rudolph, J; Tam, C; Wang, W; Xiao, Y; Young, A; Zhang, Y; Hoeflich, KP Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors. J Med Chem57:1033-45 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase PAK 4

Name:

Serine/threonine-protein kinase PAK 4

Synonyms:

KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)

Type:

Protein

Mol. Mass.:

64098.01

Organism:

Homo sapiens (Human)

Description:

O96013

Residue:

591

Sequence:

MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT
SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEE
PATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPL
SGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIP
QSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVS
HEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR
ELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAV
CLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPY
WMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHK
VSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR

BDBM50448772

n/a

Name

BDBM50448772

Synonyms:

CHEMBL3128041

Type

Small organic molecule

Emp. Form.

C19H22N6O2

Mol. Mass.

366.417

SMILES

COCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC(C)(C)O

Structure