| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxylesterase 1D |
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| Ligand | BDBM50448892 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1296363 (CHEMBL3129773) |
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| IC50 | 520±n/a nM |
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| Citation |  Otrubova, K; Cravatt, BF; Boger, DL Design, synthesis, and characterization ofa-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase. J Med Chem57:1079-89 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxylesterase 1D |
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| Name: | Carboxylesterase 1D |
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| Synonyms: | Ces1 | Ces1d | Ces3 | EST1D_MOUSE |
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| Type: | n/a |
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| Mol. Mass.: | 61787.55 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108149 |
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| Residue: | 565 |
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| Sequence: | MGLYPLIWLSLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFTQPVAVFLGVPFAKPPL
GSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLN
IYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLF
HRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKL
NLFKLDLLGNPKESYPFLPTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPT
LMGYPLAEGKLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTDDLTKKKDLFQDLMA
DVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMRPKAVIGDHGDEIFSVFGSPFLK
DGASEEETNLSKMVMKFWANFARNGNPNGGGLPHWPEYDQKEGYLKIGASTQAAQRLKDK
EVSFWAELRAKESAQRPSHREHVEL
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| BDBM50448892 |
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| n/a |
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| Name | BDBM50448892 |
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| Synonyms: | CHEMBL3125288 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O3S |
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| Mol. Mass. | 422.54 |
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| SMILES | CS(=O)C=Cc1ccc(nc1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1 |w:3.2| |
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| Structure | 
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