| Reaction Details |
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 | Report a problem with these data |
| Target | Presequence protease, mitochondrial |
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| Ligand | BDBM50449405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1294272 (CHEMBL3128914) |
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| EC50 | 152±n/a nM |
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| Citation |  Vangavaragu, JR; Valasani, KR; Gan, X; Yan, SS Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease. Eur J Med Chem76:506-16 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Presequence protease, mitochondrial |
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| Name: | Presequence protease, mitochondrial |
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| Synonyms: | KIAA1104 | MP1 | Metalloprotease 1 | PITRM1 | PREP | PREP_HUMAN | Pitrilysin metalloproteinase 1 | hMP1 | hPreP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 117419.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108043 |
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| Residue: | 1037 |
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| Sequence: | MWRCGGRQGLCVLRRLSGGHAHHRAWRWNSNRACERALQYKLGDKIHGFTVNQVTSVPEL
FLTAVKLTHDDTGARYLHLAREDTNNLFSVQFRTTPMDSTGVPHILEHTVLCGSQKYPCR
DPFFKMLNRSLSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQE
GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHTYSVVSGGDPL
CIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQIHEEALSKFQKIEPSTVVPAQ
TPWDKPREFQITCGPDSFATDPSKQTTISVSFLLPDITDTFEAFTLSLLSSLLTSGPNSP
FYKALIESGLGTDFSPDVGYNGYTREAYFSVGLQGIAEKDIETVRSLIDRTIDEVVEKGF
EDDRIEALLHKIEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQE
NPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEK
GLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRA
FSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMD
TYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHL
YASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRC
SVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIR
KLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIR
EKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVF
STVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAI
LGPENPKIAKDPSWIIQ
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| BDBM50449405 |
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| n/a |
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| Name | BDBM50449405 |
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| Synonyms: | CHEMBL3127264 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H13Br2N3O4 |
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| Mol. Mass. | 519.143 |
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| SMILES | Oc1ccc(Br)cc1Cn1c(nc2ccc(cc12)[N+]([O-])=O)-c1cc(Br)ccc1O |
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| Structure | 
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