| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50452118 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_48815 |
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| Ki | 950±n/a nM |
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| Citation |  Nazaré, M; Matter, H; Klingler, O; Al-Obeidi, F; Schreuder, H; Zoller, G; Czech, J; Lorenz, M; Dudda, A; Peyman, A; Nestler, HP; Urmann, M; Bauer, A; Laux, V; Wehner, V; Will, DW Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand. Bioorg Med Chem Lett14:2801-5 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50452118 |
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| n/a |
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| Name | BDBM50452118 |
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| Synonyms: | CHEMBL421560 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H31Cl2N3O4 |
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| Mol. Mass. | 544.469 |
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| SMILES | COc1ccc(cc1OCCc1ccc(Cl)cc1Cl)C(=O)NCC1CCN(Cc2ccnc(O)c2)CC1 |
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| Structure | 
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