Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor gamma

Ligand

BDBM50418564

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_154535 (CHEMBL857024)

EC50

4.7±n/a nM

Citation

Henke, BR; Blanchard, SG; Brackeen, MF; Brown, KK; Cobb, JE; Collins, JL; Harrington, WW; Hashim, MA; Hull-Ryde, EA; Kaldor, I; Kliewer, SA; Lake, DH; Leesnitzer, LM; Lehmann, JM; Lenhard, JM; Orband-Miller, LA; Miller, JF; Mook, RA; Noble, SA; Oliver, W; Parks, DJ; Plunket, KD; Szewczyk, JR; Willson, TM N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents. J Med Chem41:5020-36 (1999) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor gamma

Name:

Peroxisome proliferator-activated receptor gamma

Synonyms:

Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg

Type:

PROTEIN

Mol. Mass.:

57593.55

Organism:

Mus musculus

Description:

ChEMBL_1453700

Residue:

505

Sequence:

MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY

BDBM50418564

n/a

Name

BDBM50418564

Synonyms:

CHEMBL423026

Type

Small organic molecule

Emp. Form.

C32H29N3O5

Mol. Mass.

535.5898

SMILES

CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1nc2ccccc2o1

Structure