| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-P receptor |
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| Ligand | BDBM50421561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_205901 (CHEMBL814485) |
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| Ki | 1.6±n/a nM |
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| Citation |  Genicot, C; Christophe, B; Collart, P; Gillard, M; Goossens, L; Hénichart, JP; Lassoie, MA; Moureau, F; Neuwels, M; Nicolas, JM; Pasau, P; Quéré, L; Ryckmans, T; Stiernet, F; Taverne, T; Van Keulen, BJ Discovery of orally bioavailable NK1 receptor antagonists. Bioorg Med Chem Lett13:437-42 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Substance-P receptor |
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| Name: | Substance-P receptor |
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| Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46254.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25103 |
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| Residue: | 407 |
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| Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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| BDBM50421561 |
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| n/a |
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| Name | BDBM50421561 |
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| Synonyms: | CHEMBL419742 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21ClF6N2O |
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| Mol. Mass. | 466.848 |
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| SMILES | FC(F)(F)c1cc(COCC(N2CCNCC2)c2cccc(Cl)c2)cc(c1)C(F)(F)F |
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| Structure | 
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