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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Ligand | BDBM50000460 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3411 | ||
| Ki | 0.32±n/a nM | ||
| Citation |  Clark RD; Miller AB; Berger J; Repke DB; Weinhardt KK; Kowalczyk BA; Eglen RM; Bonhaus DW; Lee CH; Michel AD 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. J Med Chem 36:2645-57 (1993) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | |||
| Name: | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Serotonin (5-HT) receptor | ||
| Synonyms: | n/a | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Serotonin (5-HT) receptor | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50000460 | |||
| n/a | |||
| Name | BDBM50000460 | ||
| Synonyms: | CHEMBL540057 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H25ClN2O | ||
| Mol. Mass. | 332.868 | ||
| SMILES | Cl.[H][C@]12CCCc3cccc(C(=O)N(C1)C1CN4CCC1CC4)c23 |r,wD:2.0,(5.24,-.81,;,-2.57,;,-1.54,;1.33,-2.33,;2.67,-1.54,;2.67,,;1.33,.77,;1.33,2.31,;,3.1,;-1.33,2.31,;-1.33,.77,;-2.67,,;-3.74,.62,;-2.67,-1.54,;-1.33,-2.33,;-4.01,-2.31,;-5.39,-1.47,;-6.79,-2.26,;-5.82,-3.45,;-4.71,-2.85,;-3.99,-3.93,;-5.4,-4.72,;-6.81,-3.88,;)| | ||
| Structure | 
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