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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A/3B | ||
| Ligand | BDBM50000466 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_3411 (CHEMBL620725) | ||
| Ki | 2.5±n/a nM | ||
| Citation |  Clark, RD; Miller, AB; Berger, J; Repke, DB; Weinhardt, KK; Kowalczyk, BA; Eglen, RM; Bonhaus, DW; Lee, CH; Michel, AD 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists. J Med Chem36:2645-57 (1993) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A/3B | |||
| Name: | 5-hydroxytryptamine receptor 3A/3B | ||
| Synonyms: | Serotonin 3 (5-HT3) receptor | Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor | ||
| Type: | n/a | ||
| Mol. Mass.: | n/a | ||
| Description: | ASSAY_ID of EBI is 2974 | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | 5-hydroxytryptamine receptor 3B | ||
| Synonyms: | 5HT3B_RAT | Htr3b | Serotonin (5-HT) receptor | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50328.78 | ||
| Organism: | Rattus norvegicus | ||
| Description: | EBI_11885 | ||
| Residue: | 437 | ||
| Sequence: |
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| Component 2 | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_RAT | 5ht3 | Htr3 | Htr3a | Serotonin (5-HT) receptor | Zacopride site-R | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 55428.70 | ||
| Organism: | RAT | ||
| Description: | 5-HT3 HTR3A RAT::P35563 | ||
| Residue: | 483 | ||
| Sequence: |
| ||
| BDBM50000466 | |||
| n/a | |||
| Name | BDBM50000466 | ||
| Synonyms: | CHEMBL540040 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H23ClN2O | ||
| Mol. Mass. | 366.884 | ||
| SMILES | Cl.O=c1n(cc(-c2ccccc2)c2ccccc12)[C@@H]1CN2CCC1CC2 |r,wU:18.19,(5.23,-1.09,;-1.33,2.77,;-1.33,1.54,;-2.68,.77,;-2.68,-.77,;-1.33,-1.54,;-1.33,-3.08,;-2.66,-3.85,;-2.65,-5.39,;-1.32,-6.16,;.02,-5.38,;.01,-3.84,;,-.77,;1.33,-1.54,;2.66,-.77,;2.66,.77,;1.33,1.54,;,.77,;-4.01,1.54,;-3.97,3.16,;-5.36,3.98,;-5.9,2.54,;-4.84,1.88,;-5.41,.72,;-6.79,1.56,;-6.77,3.18,)| | ||
| Structure | 
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