| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase |
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| Ligand | BDBM50002747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_422128 (CHEMBL908249) |
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| IC50 | 11.3±n/a nM |
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| Citation |  Mai, A; Rotili, D; Massa, S; Brosch, G; Simonetti, G; Passariello, C; Palamara, AT Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans. Bioorg Med Chem Lett17:1221-5 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase |
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| Name: | Histone deacetylase |
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| Synonyms: | Histone deacetylase HD1B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50930.01 |
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| Organism: | Zea mays |
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| Description: | ChEMBL_422128 |
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| Residue: | 458 |
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| Sequence: | MAASGEGVSLPSPAGGEDAHRRRVSYFYEPSIGDYYYGQGHPMKPHRIRMAHSLVVHYGL
HRLLELSRPYPASEADIRRFHSDDYVAFLASATGNPGVLDPRAIKRFNVGEDCPVFDGLF
PFCQASAGGSIGAAVKLNRGDADITVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKFH
RRVLYVDIDVHHGDGVEEAFFTTNRVMTVSFHKYGDFFPGTGHITDVGAAEGKHYALNVP
LSDGIDDTTFRGLFQCIIKKVMEVYQPDVVVLQCGADSLAGDRLGCFNLSVKGHADCLRF
LRSYNVPMMVLGGGGYTIRNVARCWCYETAVAVGVEPDNKLPYNDYYEYFGPDYTLHIQP
KSVENLNTTKDLENIKNMILENLSKIEHVPSTQFHDRPSDPEAPEEKEEDMDKRPPQRSR
LWSGGAYDSDTEDPDSLKSEGKDVTANFQMKDEPKDDL
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| BDBM50002747 |
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| n/a |
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| Name | BDBM50002747 |
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| Synonyms: | CHEMBL217546 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16ClN3O3S |
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| Mol. Mass. | 353.824 |
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| SMILES | ONC(=O)CCCCSc1nc(cc(=O)[nH]1)-c1ccc(Cl)cc1 |
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| Structure | 
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