Ki Summary

Reaction Details

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Target

Solute carrier family 22 member 2

Ligand

BDBM50367247

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_836107 (CHEMBL2077543)

IC50

13000±n/a nM

Citation

Goralski, KB; Lou, G; Prowse, MT; Gorboulev, V; Volk, C; Koepsell, H; Sitar, DS The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules. J Pharmacol Exp Ther303:959-68 (2002) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Solute carrier family 22 member 2

Name:

Solute carrier family 22 member 2

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

62348.38

Organism:

RAT

Description:

Adrenaline alpha2 0 RAT::Q9R0W2

Residue:

555

Sequence:

MSTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQ
RCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLG
PCEHGWVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCL
LVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGIC
YQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAM
KIIKHIAKKNGKSVPVSLQNLTPDEDAGKKLNPSFLDLVRTPQIRKHTLILMYNWFTSSV
LYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLA
SVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGII
TPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKKE
KRIYLQVKQADRPLS

BDBM50367247

n/a

Name

BDBM50367247

Synonyms:

QUININE | Quinamm | Quinsan | cid_3034034

Type

Small organic molecule

Emp. Form.

C20H24N2O2

Mol. Mass.

324.4168

SMILES

COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |THB:20:19:12.13:16.15,10:12:19.18:16.15|

Structure