| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM10862 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_956004 (CHEMBL2380061) |
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| Ki | 8300±n/a nM |
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| Citation |  Vullo, D; Luca, VD; Scozzafava, A; Carginale, V; Rossi, M; Supuran, CT; Capasso, C The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides. Bioorg Med Chem21:1534-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase 1 |
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| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM10862 |
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| n/a |
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| Name | BDBM10862 |
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| Synonyms: | 4-Amino-3-fluorobenzenesulfonamide | 4-amino-3-fluorobenzene-1-sulfonamide | CHEMBL6853 | aromatic/heteroaromatic sulfonamide 7 | halogenosulfanilamide deriv. 5b |
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| Type | Small organic molecule |
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| Emp. Form. | C6H7FN2O2S |
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| Mol. Mass. | 190.195 |
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| SMILES | Nc1ccc(cc1F)S(N)(=O)=O |
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| Structure | 
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