Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50005293 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1295421 (CHEMBL3131058) |
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Ki | 0.35±n/a nM |
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Citation | Médran-Navarrete, V; Damont, A; Peyronneau, MA; Kuhnast, B; Bernards, N; Pottier, G; Marguet, F; Puech, F; Boisgard, R; Dollé, F Preparation and evaluation of novel pyrazolo[1,5-a]pyrimidine acetamides, closely related to DPA-714, as potent ligands for imaging the TSPO 18kDa with PET. Bioorg Med Chem Lett24:1550-6 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50005293 |
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n/a |
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Name | BDBM50005293 |
Synonyms: | CHEMBL3125363 |
Type | Small organic molecule |
Emp. Form. | C25H29FN4O |
Mol. Mass. | 420.5224 |
SMILES | CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(cc1)C#CCCCF |
Structure |
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