| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM50138040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1337727 (CHEMBL3240047) |
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| IC50 | >10000±n/a nM |
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| Citation |  Tauro, M; Loiodice, F; Ceruso, M; Supuran, CT; Tortorella, P Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII. Bioorg Med Chem Lett24:1941-3 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM50138040 |
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| n/a |
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| Name | BDBM50138040 |
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| Synonyms: | (biphenyl-3-ylamino)methylenediphosphonic acid | BPH-218 | CHEMBL55371 | [(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15NO6P2 |
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| Mol. Mass. | 343.2088 |
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| SMILES | OP(O)(=O)C(Nc1cccc(c1)-c1ccccc1)P(O)(O)=O |
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| Structure | 
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