| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 8 |
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| Ligand | BDBM50003020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1335102 (CHEMBL3239609) |
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| IC50 | >67000±n/a nM |
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| Citation |  Biftu, T; Sinha-Roy, R; Chen, P; Qian, X; Feng, D; Kuethe, JT; Scapin, G; Gao, YD; Yan, Y; Krueger, D; Bak, A; Eiermann, G; He, J; Cox, J; Hicks, J; Lyons, K; He, H; Salituro, G; Tong, S; Patel, S; Doss, G; Petrov, A; Wu, J; Xu, SS; Sewall, C; Zhang, X; Zhang, B; Thornberry, NA; Weber, AE Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem57:3205-12 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 8 |
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| Name: | Dipeptidyl peptidase 8 |
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| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 103342.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q6V1X1 |
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| Residue: | 898 |
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| Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
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| BDBM50003020 |
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| n/a |
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| Name | BDBM50003020 |
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| Synonyms: | MK-3102 | OMARIGLIPTIN | US10155775, Omarigliptin | US10479798, Compound MK3102 | US10822319, Compound Omarigliptin |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20F2N4O3S |
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| Mol. Mass. | 398.428 |
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| SMILES | CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F |r| |
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| Structure | 
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