| Reaction Details |
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 | Report a problem with these data |
| Target | D(2) dopamine receptor |
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| Ligand | BDBM50322229 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1335160 (CHEMBL3239709) |
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| Ki | 0.900000±n/a nM |
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| Citation |  Xiao, J; Free, RB; Barnaeva, E; Conroy, JL; Doyle, T; Miller, B; Bryant-Genevier, M; Taylor, MK; Hu, X; Dulcey, AE; Southall, N; Ferrer, M; Titus, S; Zheng, W; Sibley, DR; Marugan, JJ Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists. J Med Chem57:3450-63 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(2) dopamine receptor |
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| Name: | D(2) dopamine receptor |
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| Synonyms: | D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 |
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| Type: | Cell-surface receptors |
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| Mol. Mass.: | 50647.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14416 |
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| Residue: | 443 |
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| Sequence: | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC
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| BDBM50322229 |
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| n/a |
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| Name | BDBM50322229 |
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| Synonyms: | 4-(4-Iodophenyl)-1-((4-methoxy-1H-indol-3-yl)methyl)-piperidin-4-ol oxalate | CHEMBL1173287 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23IN2O2 |
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| Mol. Mass. | 462.324 |
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| SMILES | COc1cccc2[nH]cc(CN3CCC(O)(CC3)c3ccc(I)cc3)c12 |
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| Structure | 
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