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TargetTranscriptional regulator ERG
LigandBDBM50003562
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1335569 (CHEMBL3239424)
IC50 20000±n/a nM
Citation Phillips, DPGao, WYang, YZhang, GLerario, IKLau, TLJiang, JWang, XNguyen, DGBhat, BGTrotter, CSullivan, HWelzel, GLandry, JChen, YJoseph, SBLi, CGordon, WPRichmond, WJohnson, KBretz, ABursulaya, BPan, SMcNamara, PSeidel, HM Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem57:3263-82 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Transcriptional regulator ERG
Name:Transcriptional regulator ERG
Synonyms:ERG | ERG_HUMAN | Transforming protein ERG
Type:PROTEIN
Mol. Mass.:54615.84
Organism:Homo sapiens (Human)
Description:ChEMBL_1335569
Residue:486
Sequence:
MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50003562
n/a
NameBDBM50003562
Synonyms:CHEMBL3234572
TypeSmall organic molecule
Emp. Form.C23H27F3N8O
Mol. Mass.488.5087
SMILESFC(F)(F)c1nc(cc(n1)N1CCC[C@H](C1)C(=O)NCCc1ccc(nc1)C#N)N1CCNCC1 |r|
Structure
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