Reaction Details |
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Target | Transcriptional regulator ERG |
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Ligand | BDBM50003283 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1335569 (CHEMBL3239424) |
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IC50 | 13000±n/a nM |
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Citation | Phillips, DP; Gao, W; Yang, Y; Zhang, G; Lerario, IK; Lau, TL; Jiang, J; Wang, X; Nguyen, DG; Bhat, BG; Trotter, C; Sullivan, H; Welzel, G; Landry, J; Chen, Y; Joseph, SB; Li, C; Gordon, WP; Richmond, W; Johnson, K; Bretz, A; Bursulaya, B; Pan, S; McNamara, P; Seidel, HM Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem57:3263-82 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transcriptional regulator ERG |
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Name: | Transcriptional regulator ERG |
Synonyms: | ERG | ERG_HUMAN | Transforming protein ERG |
Type: | PROTEIN |
Mol. Mass.: | 54615.84 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1335569 |
Residue: | 486 |
Sequence: | MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQ
QDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHM
PPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTK
DDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPN
TSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY
QILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGE
RKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPS
DLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPS
HLGTYY
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BDBM50003283 |
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n/a |
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Name | BDBM50003283 |
Synonyms: | CHEMBL3234575 |
Type | Small organic molecule |
Emp. Form. | C24H28F3N7O |
Mol. Mass. | 487.5206 |
SMILES | CN1CCN(CC1)c1cc(nc(n1)C(F)(F)F)N1CCC[C@H]1C(=O)NCCc1ccc(cc1)C#N |r| |
Structure |
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