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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50003713
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1336506 (CHEMBL3242783)
IC50 9.0±n/a nM
Citation Fox, BMSugimoto, KIio, KYoshida, AZhang, JKLi, KHao, XLabelle, MSmith, MLRubenstein, SMYe, GMcMinn, DJackson, SChoi, RShan, BMa, JMiao, SMatsui, TOgawa, NSuzuki, MKobayashi, AOzeki, HOkuma, CIshii, YTomimoto, DFurakawa, NTanaka, MMatsushita, MTakahashi, MInaba, TSagawa, SKayser, F Discovery of 6-phenylpyrimido[4,5-b][1,4]oxazines as potent and selective acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents. J Med Chem57:3464-83 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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BDBM50003713
n/a
NameBDBM50003713
Synonyms:CHEMBL3235323
TypeSmall organic molecule
Emp. Form.C25H29N3O3
Mol. Mass.419.5161
SMILESCC1(C)Oc2ncnc(N)c2C=C1c1ccc2c(CC[C@@]22CC[C@H](CC(O)=O)CC2)c1 |r,wU:20.22,wD:23.26,c:12,(61.12,-21.75,;59.58,-21.75,;60.35,-23.09,;58.25,-22.53,;56.91,-21.76,;55.58,-22.54,;54.24,-21.77,;54.25,-20.23,;55.57,-19.46,;55.57,-17.92,;56.91,-20.22,;58.24,-19.45,;59.57,-20.21,;60.9,-19.43,;60.88,-17.9,;62.21,-17.12,;63.56,-17.88,;63.57,-19.42,;65.03,-19.88,;65.93,-18.63,;65.01,-17.39,;63.91,-16.31,;64.31,-14.82,;65.79,-14.42,;66.19,-12.93,;67.68,-12.52,;68.77,-13.61,;68.08,-11.03,;66.88,-15.5,;66.49,-16.98,;62.24,-20.2,)|
Structure
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