Reaction Details |
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Target | Heat shock protein 75 kDa, mitochondrial |
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Ligand | BDBM50003869 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1336951 (CHEMBL3242259) |
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Ki | >10000±n/a nM |
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Citation | Ernst, JT; Neubert, T; Liu, M; Sperry, S; Zuccola, H; Turnbull, A; Fleck, B; Kargo, W; Woody, L; Chiang, P; Tran, D; Chen, W; Snyder, P; Alcacio, T; Nezami, A; Reynolds, J; Alvi, K; Goulet, L; Stamos, D Identification of novel HSP90a/ß isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease. J Med Chem57:3382-400 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock protein 75 kDa, mitochondrial |
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Name: | Heat shock protein 75 kDa, mitochondrial |
Synonyms: | HSP75 | TRAP1 | TRAP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 80120.13 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1478164 |
Residue: | 704 |
Sequence: | MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFS
TQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNA
SDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGS
KAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFE
IAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWM
MDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELG
SSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQL
TSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLR
EFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVT
LRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRAS
EPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
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BDBM50003869 |
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n/a |
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Name | BDBM50003869 |
Synonyms: | CHEMBL3235354 |
Type | Small organic molecule |
Emp. Form. | C26H32N2O2 |
Mol. Mass. | 404.5445 |
SMILES | Cc1cn(c2CC(C)(C)CC(=O)c12)-c1cc2CCNC(=O)c2c(c1)C1CCCCC1 |
Structure |
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