Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM50004757 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1337841 (CHEMBL3240669) |
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IC50 | 3.9±n/a nM |
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Citation | Li, X; Inks, ES; Li, X; Hou, J; Chou, CJ; Zhang, J; Jiang, Y; Zhang, Y; Xu, W Discovery of the first N-hydroxycinnamamide-based histone deacetylase 1/3 dual inhibitors with potent oral antitumor activity. J Med Chem57:3324-41 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM50004757 |
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n/a |
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Name | BDBM50004757 |
Synonyms: | CHEMBL3233698 |
Type | Small organic molecule |
Emp. Form. | C27H24ClN3O4 |
Mol. Mass. | 489.95 |
SMILES | ONC(=O)\C=C\c1ccc(OC[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)cc2)cc1 |r| |
Structure |
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