| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prolyl endopeptidase |
|---|
| Ligand | BDBM50005872 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1336166 (CHEMBL3241126) |
|---|
| Ki | 22±n/a nM |
|---|
| Citation |  Kallinen, A; Todorov, B; Kallionpää, R; Bäck, S; Sarparanta, M; Raki, M; García-Horsman, JA; Bergström, KA; Wallén, EA; Männistö, PT; Airaksinen, AJ Synthesis and biological evaluation of novel (123)I-labeled 4-(4-iodophenyl)butanoyl-L-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo. Eur J Med Chem79:436-45 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prolyl endopeptidase |
|---|
| Name: | Prolyl endopeptidase |
|---|
| Synonyms: | 3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 80758.04 |
|---|
| Organism: | Sus scrofa |
|---|
| Description: | n/a |
|---|
| Residue: | 710 |
|---|
| Sequence: | MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP
|
|
|
|---|
| BDBM50005872 |
|---|
| n/a |
|---|
| Name | BDBM50005872 |
|---|
| Synonyms: | CHEMBL3236272 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H25IN2O2 |
|---|
| Mol. Mass. | 440.3185 |
|---|
| SMILES | Ic1ccc(CCCC(=O)N2CCC[C@H]2C(=O)N2CCCC2)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
