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TargetReplication protein A 70 kDa DNA-binding subunit
LigandBDBM50006673
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1336209 (CHEMBL3241316)
Kd 2600±n/a nM
Citation Frank, AOVangamudi, BFeldkamp, MDSouza-Fagundes, EMLuzwick, JWCortez, DOlejniczak, ETWaterson, AGRossanese, OWChazin, WJFesik, SW Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem57:2455-61 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Replication protein A 70 kDa DNA-binding subunit
Name:Replication protein A 70 kDa DNA-binding subunit
Synonyms:REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:Enzyme
Mol. Mass.:68139.43
Organism:Homo sapiens (Human)
Description:P27694
Residue:616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50006673
n/a
NameBDBM50006673
Synonyms:CHEMBL3236296
TypeSmall organic molecule
Emp. Form.C81H112N18O27
Mol. Mass.1769.8604
SMILESCC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(N)=O |r|
Structure
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