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TargetReplication protein A 70 kDa DNA-binding subunit
LigandBDBM50006679
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1336209 (CHEMBL3241316)
Kd 910±n/a nM
Citation Frank, AOVangamudi, BFeldkamp, MDSouza-Fagundes, EMLuzwick, JWCortez, DOlejniczak, ETWaterson, AGRossanese, OWChazin, WJFesik, SW Discovery of a potent stapled helix peptide that binds to the 70N domain of replication protein A. J Med Chem57:2455-61 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Replication protein A 70 kDa DNA-binding subunit
Name:Replication protein A 70 kDa DNA-binding subunit
Synonyms:REPA1 | RF-A protein 1 | RFA1_HUMAN | RP-A p70 | RPA1 | RPA70 | Replication factor A protein 1 | Single-stranded DNA-binding protein
Type:Enzyme
Mol. Mass.:68139.43
Organism:Homo sapiens (Human)
Description:P27694
Residue:616
Sequence:
MVGQLSEGAIAAIMQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLAT
QLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYNE
GLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGT
QSKVVPIASLTPYQSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNE
QVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNETSVMPCEDDHHLPTVQF
DFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATL
WGEDADKFDGSRQPVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQ
ALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFSSVATVVYLRKENCMYQA
CPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAIL
GQNAAYLGELKDKNEQAFEEVFQNANFRSFIFRVRVKVETYNDESRIKATVMDVKPVDYR
EYGRRLVMSIRRSALM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50006679
n/a
NameBDBM50006679
Synonyms:CHEMBL3236300
TypeSmall organic molecule
Emp. Form.C88H99N15O28S
Mol. Mass.1846.876
SMILESCC(C)C[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=S)Nc1ccc(c(c1)C(O)=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)[C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O |r,wU:16.16,29.29,4.3,116.123,44.45,78.84,93.98,wD:84.89,8.8,33.33,102.107,24.24,127.135,(45.14,-14.1,;43.8,-13.34,;43.8,-11.8,;42.46,-14.1,;42.46,-15.64,;41.13,-16.41,;39.8,-15.64,;39.8,-14.1,;38.47,-16.41,;38.47,-17.95,;39.8,-18.71,;41.13,-17.95,;39.8,-20.26,;37.13,-15.63,;35.81,-16.4,;35.81,-17.95,;34.47,-15.64,;34.47,-14.09,;35.81,-13.33,;37.13,-14.09,;35.81,-11.79,;33.14,-16.41,;31.8,-15.63,;31.8,-14.09,;30.47,-16.41,;30.47,-17.95,;29.14,-15.63,;27.8,-16.4,;27.8,-17.94,;26.47,-15.63,;25.15,-16.4,;23.81,-15.62,;23.81,-14.09,;22.47,-16.4,;22.47,-17.94,;23.81,-18.7,;23.8,-20.24,;25.12,-21.02,;26.45,-20.25,;26.45,-18.71,;25.13,-17.94,;21.14,-15.62,;19.81,-16.4,;19.81,-17.93,;18.48,-15.62,;18.48,-14.08,;19.81,-13.31,;21.15,-14.08,;19.81,-11.78,;17.14,-16.4,;15.82,-15.61,;15.84,-14.07,;14.47,-16.36,;13.15,-15.58,;11.82,-16.32,;10.49,-15.53,;10.51,-13.99,;11.86,-13.24,;13.19,-14.03,;12.27,-11.76,;13.76,-11.37,;11.19,-10.66,;9.18,-13.2,;7.85,-13.94,;7.83,-15.48,;6.47,-16.23,;5.15,-15.44,;3.79,-16.19,;5.18,-13.9,;6.52,-13.15,;6.54,-11.61,;7.9,-10.87,;7.92,-9.32,;9.26,-8.57,;9.28,-7.01,;10.59,-9.37,;10.56,-10.9,;9.21,-11.66,;26.47,-14.09,;25.15,-13.32,;27.8,-13.32,;43.8,-16.41,;43.8,-17.96,;45.13,-15.64,;46.46,-16.42,;46.46,-17.96,;47.8,-18.72,;47.8,-20.27,;46.45,-21.04,;49.12,-21.04,;47.8,-15.65,;47.8,-14.11,;49.13,-16.42,;50.46,-15.65,;50.46,-14.11,;51.79,-13.35,;51.79,-11.81,;50.46,-11.04,;53.14,-11.04,;51.79,-16.42,;51.79,-17.97,;53.13,-15.65,;54.46,-16.43,;54.46,-17.97,;55.79,-18.73,;57.19,-18.12,;58.22,-19.26,;57.46,-20.59,;57.92,-22.06,;56.9,-23.21,;55.39,-22.88,;54.91,-21.42,;55.95,-20.27,;55.79,-15.66,;55.79,-14.12,;57.12,-16.43,;58.46,-15.66,;58.46,-14.12,;59.79,-13.36,;59.79,-11.82,;61.13,-11.05,;62.46,-11.82,;62.46,-13.36,;61.12,-14.13,;59.79,-16.43,;59.79,-17.98,;61.12,-15.66,;62.45,-16.44,;62.45,-17.98,;63.79,-15.67,;65.13,-16.44,;63.79,-14.13,)|
Structure
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