Reaction Details |
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Target | Histamine H4 receptor |
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Ligand | BDBM50006788 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1336216 (CHEMBL3241464) |
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Ki | 5.0±n/a nM |
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Citation | Savall, BM; Chavez, F; Tays, K; Dunford, PJ; Cowden, JM; Hack, MD; Wolin, RL; Thurmond, RL; Edwards, JP Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H4 receptor antagonists. J Med Chem57:2429-39 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H4 receptor |
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Name: | Histamine H4 receptor |
Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44517.02 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
Residue: | 390 |
Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50006788 |
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n/a |
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Name | BDBM50006788 |
Synonyms: | CHEMBL3236548 |
Type | Small organic molecule |
Emp. Form. | C24H31FN4O |
Mol. Mass. | 410.5275 |
SMILES | CN1CCC(CCCCOc2cc(-c3nc4c(C)c(F)ccc4[nH]3)c(C)cn2)CC1 |
Structure |
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