Reaction Details | |||
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Target | Prostaglandin D2 receptor 2 | ||
Ligand | BDBM50006830 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1336707 (CHEMBL3240855) | ||
IC50 | 1.2±n/a nM | ||
Citation | Kaila, N; Follows, B; Leung, L; Thomason, J; Huang, A; Moretto, A; Janz, K; Lowe, M; Mansour, TS; Hubeau, C; Page, K; Morgan, P; Fish, S; Xu, X; Williams, C; Saiah, E Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases. J Med Chem57:1299-322 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Prostaglandin D2 receptor 2 | |||
Name: | Prostaglandin D2 receptor 2 | ||
Synonyms: | CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 43295.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q9Y5Y4 | ||
Residue: | 395 | ||
Sequence: |
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BDBM50006830 | |||
n/a | |||
Name | BDBM50006830 | ||
Synonyms: | CHEMBL3236948 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H21FN2O3 | ||
Mol. Mass. | 392.4228 | ||
SMILES | CC(C)n1cc(-c2c(C)n(CC(O)=O)c3ccc(F)cc23)c2ccccc2c1=O |(57.2,-40.02,;55.86,-39.25,;55.86,-37.71,;54.53,-40.02,;54.52,-41.56,;53.19,-42.33,;53.19,-43.87,;54.43,-44.77,;55.89,-44.3,;53.95,-46.24,;54.86,-47.48,;56.39,-47.32,;57.02,-45.92,;57.29,-48.57,;52.41,-46.24,;51.39,-47.37,;49.89,-47.06,;49.41,-45.59,;47.9,-45.27,;50.44,-44.45,;51.94,-44.77,;51.86,-41.56,;50.54,-42.33,;49.21,-41.57,;49.2,-40.03,;50.53,-39.26,;51.86,-40.03,;53.19,-39.25,;53.19,-37.71,)| | ||
Structure |